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Overview and Prevalence of Genetic Defects
|
|
Age at diagnosis |
Disease |
Mode of inheritance |
Disease frequency |
Guesstimation of gene frequency (%carriers) |
1 |
<8 years |
Hypothyroidism |
R |
5.0/100 |
34.7% |
2 |
<5 years |
Addison's disease |
UND |
0.2/100 |
8.4% |
3 |
<8 years |
Hyperadrenocorticism |
UND |
0.1/100 |
6.0% |
4 |
<3 years |
Diabetes mellitus |
UND |
0.06/100 |
4.7% |
5 |
<4 years |
Hyperparathyroidism |
UND |
0.06/100 |
4.7% |
6 |
<4 years |
Autoimmune hemolytic anemia |
UND |
0.1/100 |
6.0% |
7 |
<6 years |
Immune mediated polyarthritis |
UND |
0.06/100 |
4.7% |
8 |
<10 years |
Immune mediated thrombocytopenia |
UND |
0.06/100 |
4.7% |
9 |
<9 years |
Systemic lupus erythematosus |
UND |
0.06/100 |
4.7% |
10 |
<1 year |
Von Willebrand's disease |
R, Dinc |
0.06/100 |
4.7% |
11 |
birth |
Hemophilia |
X-R |
0.06/100 |
4.7% |
12 |
>4 years |
Mast cell tumor |
POLY |
3.5/100 |
30.5% |
13 |
>4 years |
Hemangiosarcoma |
POLY |
0.6/100 |
14.2% |
14 |
Birth |
Ridgelessness |
Complex |
10.6/100 |
43.9% |
15 |
<3 months |
Dermoid sinus |
R |
4.7/100 |
33.9% |
16 |
<1 year |
Demodicosis |
UND |
1.5/100 |
21.4% |
17 |
<1 year |
Atopic dermatitis |
UND |
3.6/100 |
30.6% |
18 |
<1 year |
Food allergies |
UND |
1.2/100 |
19.4% |
19 |
<5 years |
Seasonal flank alopecia |
UND |
0.1/100 |
6.0% |
20 |
<10 weeks |
Ehlers Danlos syndrome |
D |
0.06/100 |
4.7% |
21 |
<10 weeks |
Umbilical hernia |
R/Poly |
0.5/100 |
13.1% |
22 |
<6 months |
Megaesophagus |
R/UND |
0.9/100 |
17.0% |
23 |
<7 years |
Pancreatic hypoplasia |
R |
0.06/100 |
4.7% |
24 |
<1 year |
Gastric Dilatation/Volvulus |
UND |
0.9/100 |
17.0% |
25 |
<1 year |
Subaortic stenosis |
POLY |
0.2/100 |
8.4% |
26 |
< 2 years |
Cardiomyopathy |
POLY |
0.1/100 |
6.0% |
27 |
Birth |
Persistent right aortic arch |
POLY |
0.06/100 |
4.7% |
28 |
<1 year |
Pulmonary stenosis |
POLY |
0.06/100 |
4.7% |
29 |
<1 year |
Laryngeal paralysis |
D |
0.06/100 |
4.7% |
30 |
<1 year |
Tracheal collapse |
UND |
0.1/100 |
6.0% |
31 |
<3 months |
Cryptorchidism |
R/UND |
1.0/100 |
18.0% |
32 |
>1 year |
Seizures (epilepsy) |
R/UND |
0.7/100 |
15.2% |
33 |
>1 year |
Degenerative myelopathy |
UND |
0.5/100 |
13.1% |
34 |
<6 months |
Deafness |
UND |
0.3/100 |
10.2% |
35 |
</= 1 year |
Wobbler syndrome |
POLY |
0.1/100 |
6.0% |
36 |
<9 years |
Cauda equina syndrome |
UND |
0.06/100 |
4.7% |
37 |
<3 months |
Hydrocephalus |
POLY |
0.06/100 |
4.7% |
38 |
<1 year |
Lumbar stenosis |
UND |
0.06/100 |
4.7% |
39 |
<2 years |
Hip dysplasia |
POLY |
2.20/100 |
25.2% |
40 |
<1 year |
Dental abnormalities |
UND |
1.40/100 |
20.8% |
41 |
<1 year |
OCD/FCP (elbow dysplasia) |
POLY |
0.7/100 |
15.2% |
42 |
<1 year |
Luxating patella |
R |
0.10/100 |
6.0% |
43 |
<1 year |
Osteochondritis dissecans |
UND |
0.4/100 |
11.7% |
44 |
<1 year |
Congenital vertebral abnormalities |
UND |
0.3/100 |
10.2% |
45 |
<3 months |
Open fontanelle |
UND |
0.2/100 |
8.4% |
46 |
>1 year |
Spondylosis deformans |
POLY |
0.2/100 |
8.4% |
47 |
<4 months |
Pectus excavatum |
UND |
0.1/100 |
6.0% |
48 |
Birth |
Cleft palate |
POLY/UND |
0.1/100 |
6.0% |
49 |
<8 months |
Hypertrophic osteodystrophy |
UND |
0.1/100 |
6.0% |
50 |
varies |
Cataracts |
UND |
1.0/100 |
18.0% |
51 |
<6 months |
Entropion |
UND |
0.6/100 |
14.2% |
52 |
<3 months |
Persistent pupillary membranes |
UND |
0.2/100 |
8.4% |
53 |
<3 years |
Glaucoma |
UND |
0.1/100 |
6.0% |
54 |
<6 months |
Ectropion |
UND |
0.6/100 |
4.7% |
55 |
varies |
Corneal dystrophy |
UND |
0.6/100 |
4.7% |
56 |
Birth |
Microphthalmia |
UND |
0.6/100 |
4.7% |
57 |
<= 3 years |
Excessive aggression |
UND |
1.8/100 |
23.2% |
58 |
<1 year |
Excessive Shyness |
UND |
0.8/100 |
16.2% |
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